NIPH Clinical Trials Search

The effect of keora oral moisture mist/gel on bad breath and periodontitis

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	periodontal disease
Date of first enrollment	20/01/2026
Target sample size	20
Countries of recruitment
Study type	Interventional
Intervention(s)	After obtaining consent, a preliminary examination will be conducted, including a periodontitis test and oral function tests (saliva volume measurement, tongue coating evaluation, oral dryness evaluation, saliva viscosity evaluation, occlusal force test, chewing function test, and bacterial type and quantity test). After that, keora Oral Moisture Mist will be used (3 pumps (0.6g) per time) and the bad breath suppression effect will be measured (using Oral Chroma) 10 minutes later. A one-day flush-out period will be set, and from the day after tomorrow, brushing with keora Oral Moisture Gel (3 pumps (0.6g) per time) will be performed twice a day (morning and evening) after regular brushing for a total of 5 days.

Outcome(s)

Primary Outcome	Bad breath measurement (measurement of volatile sulfur compound concentration in breath using OralChroma)
Secondary Outcome	PISA (Periodontal Inflamed Surface Area) Saliva volume measurement Tongue coating degree (TCI Oral dryness using the Mucus oral moisture mete Saliva viscosity using the NEVA METER Biting force test Chewing function using Glucosensor II Quantification of periodontal pathogenic bacteria (ORCOA) Measurement of oral bacterial load

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	Not applicable
Gender	Both
Include criteria	1. Patients with periodontitis 2. Patients who are 18 years of age or older at the time of obtaining consent. 3. Patients who are able to visit the clinic in the same time on the study start date and 7 days thereafter. 4. Patients who can provide written consent to participate in this study.
Exclude criteria	1. Patients whose living environment will change during the intervention period. 2. Patients who have taken oral or intravenous antibiotics or eye drops within 14 days prior to the start of the intervention. 3. Patients who have taken oral or intravenous immunosuppressants or steroids within 14 days prior to the start of the intervention. 4. Patients with less than 20% of plaque control records (PCR: a method of evaluating brushing based on plaque adhesion) prior to the start of the intervention. 5. Patients who have difficulty holding a toothbrush.