NIPH Clinical Trials Search

Cerebral White Matter Stimulation Using Noninvasive Methods

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Not applicable, as the participants are healthy volunteers.
Date of first enrollment	25/05/2026
Target sample size	15
Countries of recruitment
Study type	Interventional
Intervention(s)	At the first session, MRI scans for navigation purposes will be acquired. During the second session, the primary motor cortex will first be stimulated using a transcranial magnetic stimulation device with navigation and motor evoked potentials (MEPs) to confirm that responses can be elicited. Subsequently, one of the following tasks will be performed before and after transcranial ultrasound stimulation. Part A: muscle strength assessment (measured using motor evoked potentials); Part B: object naming and verbal fluency tasks; Part C: line bisection test and star cancellation test. Finally, a questionnaire regarding adverse events will be administered.

Outcome(s)

Primary Outcome	Safety, Detectability
Secondary Outcome	This includes the completion status of all MRI, transcranial magnetic stimulations, transcranial ultrasound stimulations, brain function tests, and adverse event questionnaires.

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	< 75age old
Gender	Both
Include criteria	Healthy adult volunteers who meet the following criteria Aged 18 to 75 years Not currently receiving treatment with any pharmaceuticals or medical devices No diseases or medical history that meet the exclusion criteria
Exclude criteria	1) Individuals who are currently undergoing treatment with oral medications for neuropsychiatric disorders or who have a history of such disorders. 2) Individuals with a history of neurodegenerative diseases, psychiatric disorders, or head trauma. 3) Individuals with a history of seizures (excluding those with a past history, even if they are not currently taking medication). 4) Individuals with claustrophobia. 5) Individuals in socially vulnerable positions, such as those affiliated with the Department of Neurosurgery or enrolled in its programs.