NIPH Clinical Trials Search

Efficacy of rTMS for upper limb paralysis after stroke

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Stroke
Date of first enrollment	07/01/2026
Target sample size	88
Countries of recruitment
Study type	Interventional
Intervention(s)	repetitive Transcranial Magnetic Stimulation

Outcome(s)

Primary Outcome	Fugl-Meyer Assessment for upper extremity item
Secondary Outcome	Subtest scores Fugl-Meyer Assessment for upper extremity item, ARAT (Action Research Arm Test), BBT(Box & Block Test), Motor evoked potential elicited by transcranial magnetic stimulation, ipsilateral silent period by transcranial magnetic stimulation *Study2 only, Magnetic resonance imaging, Safety Assessments

Key inclusion & exclusion criteria

Age minimum	>= 20age old
Age maximum	<= 80age old
Gender	Both
Include criteria	Study1 (1) Age: 20-80 (2) Under the agreement with written consent form (3) Diagnosed as stroke by a physician (4) Inpatient at Chiba Rehabilitation Center (5) 2 months after onset (6) MEPs appears (7) Fugl-Meyer Assessment for upper extremity item of 20 or more (8) The weekly upper extremity motor score is limited to a change within the standard error for two consecutive weeks Study2 (1) Age: 20-80 (2) Under the agreement with written consent form (3) Diagnosed as stroke by a physician (4) Inpatient at Chiba Rehabilitation Center (5) 2 months after onset (6) MEPs does not appear. (7) Fugl-Meyer Assessment for upper extremity item are 19 points or less (8) The weekly upper extremity motor score is limited to a change within the standard error for two consecutive weeks
Exclude criteria	(1) Fit into following cases History of harmful sides effects due to magnetic or electrical stimulation. History of seizure or epilepsy. Disease or injury of head, brain, peripheral nerves including brain surgery prior to the onset of the current illness or injury. Medical device implantation such as cardiac pacemaker, neurosurgical clips, battery or pumps, non-titanium metal implants in the head or the stimulus target area of trunk. Chronic severe migraine, Suspicion of pregnancy (2) Buried metal cannot be identified as titanium. (3) Inappropriate patient decided by a physician (4) Current participation in clinical trials for an approved drug or clinical device (5) History of botulinum toxin therapy within 3 months (6) Over 57 points the FMA for upper extremity item