NIPH Clinical Trials Search

Bomedemstat (MK-3543) Definitive Food Effect Study

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Essential thrombocythaemia
Date of first enrollment	16/02/2026
Target sample size	32
Countries of recruitment
Study type	Interventional
Intervention(s)	Treatment of MK-3543

Outcome(s)

Primary Outcome	MK-3543 PK
Secondary Outcome	Adveres event

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	<= 64age old
Gender	Both
Include criteria	1) Be in good health based on medical history, physical examination, vital sign measurements, 12-lead ECGs at the Screening Visit and before administration of the dose of the study intervention. 2) BMI >= 18.5 and <= 32.0 kg/m2, inclusive, with a body weight >= 50 and<=100 kg. 3) Is an individual of any sex/gender, from 18 years to 64 years of age inclusive, at the time of providing the informed consent.
Exclude criteria	1) History of clinically significant endocrine, GI, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. 2) History of cancer (malignancy).