NIPH Clinical Trials Search

A study comparing total underwater colonoscopy and CO2 insufflation colonoscopy

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Colorectal neoplasms
Date of first enrollment	27/04/2026
Target sample size	50
Countries of recruitment
Study type	Interventional
Intervention(s)	Tandem colonoscopy is performed for each case. Insertion is performed by immersion in both groups. Random classification into the following two groups will be performed for extraction. Intervention 1: Extraction will be performed by water immersion first, followed by CO2 insufflation. Intervention 2: Extraction will be performed first by CO2 insufflation, followed by water immersion.

Outcome(s)

Primary Outcome	polyp miss rate and adenoma miss rate
Secondary Outcome	Polyp and adenoma detection rate, endoscopic extraction time, assessment of pain during examination, sedative dosage

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	Not applicable
Gender	Both
Include criteria	1. Patients undergoing inpatient treatment for colorectal tumors 2. Patients aged 18 years or older at the time of obtaining informed consent 3. No restriction on sex 4. Patients who have received sufficient explanation regarding participation in this study and have provided written informed consent of their own free will with adequate understanding
Exclude criteria	1. Patients with a history of colorectal surgery(excluding appendectomy) 2. Patients with inflammatory bowel disease 3. Patients with polyposis 4. Patients with heart failure(NYHA class III or IV) 5. Patients with severe hepatic dysfunction (Child Pugh class B or C) 6. Patients with chronic renal failure undergoing hemodialysis or peritoneal dialysis 7. Pregnant patients 8. Patients deemed ineligible for this study by the investigator