NIPH Clinical Trials Search

Randomized Controlled Trial of the Modified Killian Method

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	Head and neck squamous cell carcinoma and esophageal squamous cell carcinoma (high-risk population)
Date of first enrollment	25/03/2026
Target sample size	56
Countries of recruitment
Study type	Interventional
Intervention(s)	Hypopharyngeal observation will be performed using an ultrathin endoscope. Participants will undergo both the conventional Valsalva method and the Modified Killian method in a randomized crossover design. The Modified Killian method uses neck flexion and head rotation to improve visualization.

Outcome(s)

Primary Outcome	Hypopharyngeal visibility score assessed using the Murono score
Secondary Outcome	1. Visibility of the pyriform sinus 2. Lesion detection rate 3. Observation time 4. Adverse events 5. Patient discomfort

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	Not applicable
Gender	Both
Include criteria	1. Patients with a history of esophageal squamous cell carcinoma or head and neck squamous cell carcinoma 2. Age over 18 years 3. Written informed consent obtained
Exclude criteria	1. Advanced cancer in the pharyngolaryngeal region 2. Inability to maintain a sitting position 3. Cervical spine disorders preventing neck movement 4. Pregnancy or suspected pregnancy 5. Patients judged inappropriate by investigators