NIPH Clinical Trials Search

A study to see whether giving amino acids during heart surgery can help protect the kidneys

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Acute Kidney Injury
Date of first enrollment	01/01/2023
Target sample size	300
Countries of recruitment
Study type	Observational
Intervention(s)

Outcome(s)

Primary Outcome

Presence or absence of acute kidney injury (AKI), assessed using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria

Secondary Outcome

Severity of AKI,Duration of AKI,Duration of renal impairment (serum creatinine > 168 mmol/L),Time course of estimated glomerular filtration rate (eGFR),Urine output,Use of renal replacement therapy (RRT),Duration of RRT,Transition to maintenance hemodialysis,Serum urea level,Fluid balance (input-output balance),Duration of oliguria,Use of diuretics,Length of stay in the intensive care unit (ICU),Use of vasopressors,Duration of mechanical ventilation,Reoperation,Change in antibiotics,Atrial fibrillation,Ventricular fibrillation,Ventricular tachycardia,Cardiopulmonary resuscitation (CPR),Stroke,Mortality

Key inclusion & exclusion criteria

Age minimum	Not applicable
Age maximum	Not applicable
Gender	Both
Include criteria	Patients who underwent cardiovascular surgery with cardiopulmonary bypass at Hamamatsu University School of Medicine Hospital between January 1, 2023 and August 31, 2025
Exclude criteria	1.Patients in whom hemodialysis has been initiated preoperatively or is planned postoperatively 2.Patients with chronic kidney disease stage IV or higher 3.Cases in which the patient or the patient's legal representative refuses or withdraws participation in this study 4.Cases found after enrollment not to meet the eligibility criteria 5.Patients with an allergy to amino acid preparations