NIPH Clinical Trials Search

Research on Improving EV Quality

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	IVF patients
Date of first enrollment	18/03/2026
Target sample size	30
Countries of recruitment
Study type	Observational
Intervention(s)

Outcome(s)

Primary Outcome	Apoptosis in blastocysts (percentage of TUNEL-positive cells)
Secondary Outcome	1. Embryonic development 2. Exploratory analysis using RNA-seq (discarded frozen embryos from normal fertilization only) 3. Metabolic stress markers (discarded frozen embryos from normal fertilization only)

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	< 50age old
Gender	Both
Include criteria	1. Individuals whose patient background (age, treatment history, egg retrieval conditions, etc.) can be verified through medical records 2. For abnormal embryos, individuals for whom written consent for research use was obtained prior to egg retrieval 3. For normal embryos, individuals for whom the embryos became unnecessary after treatment concluded, and for whom written consent for research use was obtained after the decision to discard them was made 4. Individuals for whom written consent to participate in the study was obtained
Exclude criteria	1. Individuals whom the principal investigator or a co-investigator deems unsuitable for inclusion in the study