NIPH Clinical Trials Search

Comparison of hemodynamic changes between high-flow nasal oxygen therapy and face mask ventilation during anesthetic induction in cardiovascular surgery

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	Patients aged 70 years or older scheduled to undergo cardiovascular surgery under general anesthesia
Date of first enrollment	18/05/2026
Target sample size	60
Countries of recruitment
Study type	Interventional
Intervention(s)	High-flow nasal oxygen therapy

Outcome(s)

Primary Outcome	Incidence of hypotension (defined as a mean arterial pressure < 65 mmHg)
Secondary Outcome	Total dose of vasopressors administered during anesthetic induction Incidence of hypoxemia (defined as a oxygen saturation of < 95%)

Key inclusion & exclusion criteria

Age minimum	>= 70age old
Age maximum	Not applicable
Gender	Both
Include criteria	1. Patients scheduled to undergo cardiovascular surgery under general anesthesia 2. Patients in whom remimazolam is used as the sedative agent for anesthesia induction 3. Patients aged 70 years or older at the time of informed consent 4. Patients with an American Society of Anesthesiologists Physical Status classification of 2 and 3 Class II: Patients with mild to moderate systemic disease Class III: Patients with severe systemic disease 5. Patients who have provided written informed consent to participate in this study
Exclude criteria	1. Patients undergoing emergency surgery 2. Patients who may be pregnant 3. Patients with anticipated difficult airway or difficult intubation 4. Patients with a body mass index (BMI) of 35 or higher (kg / m^2 ) 5. Patients with high risk of aspiration 6. Patients with conditions in which carbon dioxide retention is undesirable (e.g., pulmonary hypertension, right heart failure)