NIPH Clinical Trials Search

Comparison of Hemodynamic Changes between High-Flow Nasal Oxygen Therapy and Face Mask Ventilation

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	Patients undergoing surgery under general anesthesia
Date of first enrollment	26/06/2025
Target sample size	60
Countries of recruitment	nonen,Japan
Study type	Interventional
Intervention(s)

Outcome(s)

Primary Outcome	Incidence of hypotension (defined as a mean arterial pressure < 65 mmHg at the point of greatest blood pressure decrease)
Secondary Outcome	Total dose of vasopressors administered during anesthesia induction Incidence of hypoxemia (defined as a lowest oxygen saturation < 95%)

Key inclusion & exclusion criteria

Age minimum	>= 70age old
Age maximum	Not applicable
Gender	Both
Include criteria	Patients scheduled to undergo surgery under general anesthesia Patients scheduled to receive remimazolam as a sedative agent for anesthesia induction Patients aged 70 years or older at the time of consent acquisition Patients classified as American Society of Anesthesiologists (ASA) Physical Status Class 1 to 3 Class 1 A normal healthy patient without organic, physiological, biochemical, or psychiatric disturbances. The surgical condition is localized and does not cause systemic disturbance. Class 2 A patient with mild to moderate systemic disease, either due to the condition requiring surgery or other pathophysiological causes. Class 3 A patient with severe systemic disease, regardless of the underlying cause or whether the degree of dysfunction can be precisely determined. Patients who have provided informed consent to participate in the study
Exclude criteria	1.Patients undergoing emergency surgery 2.Patients undergoing cardiac surgery 3.Patients who may be pregnant 4.Patients with a predicted difficult airway or anticipated difficult intubation 5.Patients with a body mass index (BMI) of 35 or higher 6.Patients considered to be at high risk of aspiration 7.Patients with conditions in which carbon dioxide retention is undesirable (e.g., pulmonary hypertension, right heart failure) 8.Patients with a history of ischemic heart disease or heart failure 9.Patients receiving dialysis