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Investigation of a sensory masking method to improve the palatability of rebamipide mouthwash in patients with pharyngeal cancer

Basic Information

Recruitment status	Recruiting
Health condition(s) or Problem(s) studied	Pharyngeal Neoplasms
Date of first enrollment	21/08/2025
Target sample size	25
Countries of recruitment
Study type	Interventional
Intervention(s)	Randomized allocation of sensory masking flavor agents added to rebamipide mouthwash.

Outcome(s)

Primary Outcome	Overall taste evaluation (VAS)
Secondary Outcome	Bitterness (VAS),Sweetness (VAS),Sourness (VAS), Astringency (VAS),Overall palatability (5-point scale),Acceptability of the formulation (5-point scale)

Key inclusion & exclusion criteria

Age minimum	>= 18age old
Age maximum	< 80age old
Gender	Both
Include criteria	Patients with pharyngeal cancer who visited the Department of Otolaryngology, University of Yamanashi Hospital, between the date of approval by the head of the research institution and September 30, 2028, and who had been continuously prescribed rebamipide mouthwash for at least 21 days. Patients who provided written informed consent to participate in this study by signing the consent form themselves.
Exclude criteria	Pregnant or lactating women. Patients who already have oral mucositis that affects their ability to eat. Patients with a history of allergy to rebamipide or the sensory masking agents. Patients unable to communicate due to cognitive impairment or other reasons. Any other individuals deemed inappropriate for inclusion by the principal investigator or co-investigators.