NIPH Clinical Trials Search

Effects of tranexamic acid on sore throat pain associated with acute upper respiratory tract infection:a multicenter, randomized, controlled trial

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	upper respiratory tract infection
Date of first enrollment	2026/07/13
Target sample size	100
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	Patients receive 1g of 50% tranexamic acid preparation three times a day. Patients receive 1g placebo (lactose) three times a day.

Outcome(s)

Primary Outcome	Primary outcome is the difference on sore throat VAS scale between 1 day after tranexamic acid is taken.
Secondary Outcome	The proportion of patients with sore throat score more than moderate level between 1 day after tranexamic acid is taken.

Key inclusion & exclusion criteria

Age minimum	18years-old
Age maximum	Not applicable
Gender	Male and Female
Include criteria	Patients of upper respiratory tract infections with a complaint of sore throat, who visited a general internal medicine department office in trial hospital from July 2026 to March 2027 were registered.
Exclude criteria	Patients with allergy to tranexamic acid and lactose, pregnant patients or patients with possibility of pregnancy, breastfeeding patients, patients who take tranexamic acid, patients who were unable to participate the study because of dementia, visual impairment and unable to answer, or complete the study form.