NIPH Clinical Trials Search

Effects of ingesting heat-killed bifidobacteria for 5 weeks on the oral condition

Basic Information

Recruitment status	Complete: follow-up complete
Health condition(s) or Problem(s) studied	N/A (Healthy adults)
Date of first enrollment	2013/09/28
Target sample size	30
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	Test food: One g of granule dextrin contained 40 mg of non-live bifidobacteria powder (more than 0.5 x 10^10 non-live cells per 1 g of the test food) Administration: Oral intake of test food twice a day for 5 weeks Placebo food: One g of granule dextrin Administration: Oral intake of placebo food twice a day for 5 weeks

Outcome(s)

Primary Outcome	Salivary IgA and IgA per mg of protein
Secondary Outcome	Oral condition and safety

Key inclusion & exclusion criteria

Age minimum	20years-old
Age maximum	40years-old
Gender	Female
Include criteria
Exclude criteria	1. Subjects with severe caries or periodontal disease 2. Subjects with removable dentures 3. Subjects who have took in antibiotic or antibacterial agent within the last month to the screening test 4. Pregnant, possibly pregnant during this study, or lactating women 5. Subjects with sever systemic diseases affecting the results of this study