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Examination of the optimal timing of temporary Spinal Cord Stimulation for herpes zoster-associated pain in the subacute phase: Multiinstitutional prospective observational study

Basic Information

Recruitment status	Complete: follow-up continuing
Health condition(s) or Problem(s) studied	Zoster-Associated Pain
Date of first enrollment	2023/04/03
Target sample size	60
Countries of recruitment	Japan
Study type	Observational
Intervention(s)

Outcome(s)

Primary Outcome

The reduction rate of VAS value between before and after tSCS treatment. If a decrease in VAS value more than 50% is observed, it has a therapeutic effect (EF), and if a decrease in VAS value less than 50% is observed, the treatment effect is poor (NE) . The optimal timing of treatment is determined by divided into two groups; Early Treatment group (ET) , Late Treatment group (LT), depending on the time of start of treatment. We examine the time when the Odd ratio between the EF group and the NE group is maximum.

Secondary Outcome

We examine the efficiency of the VAS value less than 20mm, HADS and PCS before and after tSCS treatment. We plan to examine changes in EQ-5D levels, analyze factors related to patient information and treatment effect, including spinal MRI findings, and analyze the number of complications associated with tSCS treatment.

Key inclusion & exclusion criteria

Age minimum	18years-old
Age maximum	Not applicable
Gender	Male and Female
Include criteria
Exclude criteria	(1) Women who are pregnant or may become pregnant (2) Patients whose pain disorder other than ZAP is judged by the principal investigator or co-investigator to affect the evaluation of pain for ZAP (3) Other patients who the Principal Investigator or Co-Investigator deems inappropriate as research subjects.