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The effect of regular exercise and regular exercise with teneligliptin on plasma GLP-1 concetration in the elderly patients with type 2 diabetes

Basic Information

Recruitment status	Complete: follow-up complete
Health condition(s) or Problem(s) studied	type 2 diabetes
Date of first enrollment	2013/11/01
Target sample size	20
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	no physical exercise habit physical exercise habit no physical exercise habit with treatment of 20mg/day teneligliptin physical exercise habit with treatment of 20mg/day teneligliptin

Outcome(s)

Primary Outcome	1) The changes in plasma IL-6 or GLP-1 concentration after training in the subjects with or without regular exercise 2) The changes in plasma IL-6 or GLP-1 concentration at rest in the subjects treated with or without teneligliptin, and the enchancing effect on the changes in plasma IL-6 or GLP-1 concentration by the treatment of teneligliptin
Secondary Outcome	The change in 1) fasting blood glucose, HbA1c 2) BMI 3) serum creatinine level 4) plasma IL-6 concentration 5) plasma active GLP-1 concentration 6) intima media thickness (IMT) by carotid ultrasonography

Key inclusion & exclusion criteria

Age minimum	70years-old
Age maximum	Not applicable
Gender	Male and Female
Include criteria
Exclude criteria	1) the patients wiht type 1 diabetes 2) the subjects whose HbA1cs are below 6.0% or over 8.0% 3) the subjects who cannot reduce the dosage of sulfonylureas (using more than 2mg/day of glimepiride, 1.25mg/day of glibenclamide, 40mg of gliclazide 4) the subjects with poorly-controlled hypertension (systolic blood pressure >160mmHg) 5) the subjects with a diagonosis of effort angina, chronic heart failure(class II of NHYA classification and more) and tachyarrhythmia 6) the subjects with a diagnosis of chronic respiratory failure(class II of Hugh-Jones classification and more) 7) the subjects who cannot pedal a bike for about 30min 8) the subjects with shorter time of one leg standing (<15sec) 9) the subjects in active treatment for hypothyroidism 10) the subjects with severe liver dysfunction: more than 100IU/L of AST and ALT level 11) the subjects already enrolled in other clinical trial 12) the subjects found offensive by attending physicians for this research