NIPH Clinical Trials Search

Treatment of fibrin formation with intraocular tissue plasminogen activator

Basic Information

Recruitment status	Pending
Health condition(s) or Problem(s) studied	Patients with intraocular fibrin formation
Date of first enrollment	2011/11/01
Target sample size	50
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	To the case in which intraocular fibrin is formed with the postoperative case or the pathological change in a retinal hemorrhage, steroid medicine and a nonsteroidal anti-inflammatory drug are first prescribed for the patient, and the existence of the dissolution of fibrin is observed. It is considered as the objects of this examination of the case as which the dissolution of fibrin is not regarded under the medical treatment. After explaining along with a protocol and obtaining consent, 25 microgram/0.1 ml of tPA are injected into the eye under clean operation. It is evaluated of fibrin formation on the next day, one week, one month, and three months after the injection.

Outcome(s)

Primary Outcome	The evaluation of intraocular fibrin formation at the next day of intraocular injection of tPA
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum	Not applicable
Age maximum	Not applicable
Gender	Male and Female
Include criteria
Exclude criteria	The case which has allergy in tPA