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Hepatic arterial infusion chemotherapy of cisplatin and 5-Fluorouracil versus combined intraarterial 5-Fluorouracil and subcutaneous Interferon-alpha therapy in treating patients with unresectable liver cancer

Basic Information

Recruitment status	Complete: follow-up complete
Health condition(s) or Problem(s) studied	Hepatocellular carcinoma
Date of first enrollment	2004/06/01
Target sample size	100
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	Hepatic arterial infusion chemotherapy of cisplatin and 5-Fluorouracil Continue the protocol as long as possible. combined intraarterial 5-Fluorouracil and subcutaneous Interferon-alpha therapy Continue the protocol as long as possible.

Outcome(s)

Primary Outcome	Overall survival
Secondary Outcome	Time to treatment failure Incidence of adverse events

Key inclusion & exclusion criteria

Age minimum	Not applicable
Age maximum	Not applicable
Gender	Male and Female
Include criteria
Exclude criteria	High risk patient for esophageal varices rupture Malignant disease except hepatocellular carcinoma Allergy for 5FU, cisplatin, or interferron Severe heart disease psychiatric disorder Uncontrorable pleural effusion, ascites, or cardiac effusion